Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3123661..3124256 Replicon chromosome
Accession NZ_LR536430
Organism Escherichia coli isolate f974b26a-5e81-11e8-bf7f-3c4a9275d6c8

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag E4Z69_RS15540 Protein ID WP_000239581.1
Coordinates 3123906..3124256 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag E4Z69_RS15535 Protein ID WP_001223213.1
Coordinates 3123661..3123912 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4Z69_RS15525 3119326..3123105 + 3780 WP_001548968.1 autotransporter assembly complex protein TamB -
E4Z69_RS15530 3123108..3123449 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
E4Z69_RS15535 3123661..3123912 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
E4Z69_RS15540 3123906..3124256 + 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
E4Z69_RS15545 3124335..3124865 - 531 WP_000055072.1 inorganic diphosphatase -
E4Z69_RS15550 3125175..3126131 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
E4Z69_RS15555 3126269..3127771 + 1503 WP_001095667.1 sugar ABC transporter ATP-binding protein -
E4Z69_RS15560 3127785..3128807 + 1023 WP_001548970.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T288395 WP_000239581.1 NZ_LR536430:3123906-3124256 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT288395 WP_001223213.1 NZ_LR536430:3123661-3123912 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References