Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3012327..3012824 Replicon chromosome
Accession NZ_LR536430
Organism Escherichia coli isolate f974b26a-5e81-11e8-bf7f-3c4a9275d6c8

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag E4Z69_RS14990 Protein ID WP_001173343.1
Coordinates 3012651..3012824 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag E4Z69_RS14985 Protein ID WP_001425728.1
Coordinates 3012327..3012623 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4Z69_RS14960 3008282..3009001 - 720 WP_000611288.1 two-component system response regulator DcuR -
E4Z69_RS14965 3008998..3010629 - 1632 WP_001216486.1 sensor histidine kinase -
E4Z69_RS14970 3010810..3011040 + 231 WP_000371700.1 (4Fe-4S)-binding protein -
E4Z69_RS14975 3011071..3011768 - 698 Protein_2879 IS1 family transposase -
E4Z69_RS14980 3011828..3012100 + 273 WP_000405647.1 N-acetyltransferase -
E4Z69_RS14985 3012327..3012623 + 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
E4Z69_RS14990 3012651..3012824 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
E4Z69_RS14995 3012943..3014460 - 1518 WP_001295074.1 lysine--tRNA ligase -
E4Z69_RS15000 3014697..3016154 - 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T288394 WP_001173343.1 NZ_LR536430:3012651-3012824 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT288394 WP_001425728.1 NZ_LR536430:3012327-3012623 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References