Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2211438..2212069 Replicon chromosome
Accession NZ_LR536430
Organism Escherichia coli isolate f974b26a-5e81-11e8-bf7f-3c4a9275d6c8

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag E4Z69_RS11325 Protein ID WP_001259385.1
Coordinates 2211794..2212069 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag E4Z69_RS11320 Protein ID WP_000593555.1
Coordinates 2211438..2211797 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4Z69_RS11295 2207570..2208514 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
E4Z69_RS11300 2208511..2209344 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
E4Z69_RS11305 2209344..2210108 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
E4Z69_RS11310 2210105..2210911 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
E4Z69_RS11315 2210917..2211318 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
E4Z69_RS11320 2211438..2211797 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E4Z69_RS11325 2211794..2212069 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
E4Z69_RS11330 2212142..2213266 - 1125 WP_001488398.1 ABC transporter permease -
E4Z69_RS11335 2213266..2216001 - 2736 WP_000149123.1 ribosome-associated ATPase/putative transporter RbbA -
E4Z69_RS11340 2215998..2217065 - 1068 WP_000361470.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T288393 WP_001259385.1 NZ_LR536430:c2212069-2211794 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT288393 WP_000593555.1 NZ_LR536430:c2211797-2211438 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References