Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4622149..4622984 Replicon chromosome
Accession NZ_LR217818
Organism Escherichia coli strain NCTC86

Toxin (Protein)


Gene name yeeV Uniprot ID A0A5F0P695
Locus tag E4V11_RS22650 Protein ID WP_022645116.1
Coordinates 4622607..4622984 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q5I3J0
Locus tag E4V11_RS22645 Protein ID WP_001280951.1
Coordinates 4622149..4622517 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4V11_RS22610 4617813..4618493 + 681 WP_001282921.1 WYL domain-containing protein -
E4V11_RS22615 4618641..4619318 + 678 WP_001097302.1 hypothetical protein -
E4V11_RS22620 4619324..4619557 + 234 WP_001278293.1 DUF905 family protein -
E4V11_RS22625 4619647..4620465 + 819 WP_001175165.1 DUF945 domain-containing protein -
E4V11_RS22630 4620731..4621210 + 480 WP_001564060.1 antirestriction protein -
E4V11_RS22635 4621226..4621702 + 477 WP_001186786.1 RadC family protein -
E4V11_RS22640 4621765..4621986 + 222 WP_021532904.1 DUF987 domain-containing protein -
E4V11_RS22645 4622149..4622517 + 369 WP_001280951.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
E4V11_RS22650 4622607..4622984 + 378 WP_022645116.1 TA system toxin CbtA family protein Toxin
E4V11_RS22655 4622981..4623130 + 150 Protein_4357 hypothetical protein -
E4V11_RS22660 4623209..4623403 + 195 WP_024181941.1 DUF957 domain-containing protein -
E4V11_RS22665 4623488..4624330 + 843 WP_022645115.1 DUF4942 domain-containing protein -
E4V11_RS22670 4625079..4626618 + 1540 Protein_4360 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4588659..4634430 45771


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14021.99 Da        Isoelectric Point: 7.8045

>T288370 WP_022645116.1 NZ_LR217818:4622607-4622984 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGIALCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13699.56 Da        Isoelectric Point: 7.0268

>AT288370 WP_001280951.1 NZ_LR217818:4622149-4622517 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5F0P695

Antitoxin

Source ID Structure
AlphaFold DB Q5I3J0

References