Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2782263..2782901 Replicon chromosome
Accession NZ_LR217818
Organism Escherichia coli strain NCTC86

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag E4V11_RS13780 Protein ID WP_000813794.1
Coordinates 2782263..2782439 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E4V11_RS13785 Protein ID WP_001270286.1
Coordinates 2782485..2782901 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4V11_RS13760 2777882..2779096 - 1215 WP_001326689.1 BenE family transporter YdcO -
E4V11_RS13765 2779149..2779685 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
E4V11_RS13770 2779758..2781719 + 1962 WP_066009051.1 23S rRNA 5-hydroxycytidine C2501 synthase -
E4V11_RS13775 2781811..2782041 - 231 WP_000494244.1 YncJ family protein -
E4V11_RS13780 2782263..2782439 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
E4V11_RS13785 2782485..2782901 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
E4V11_RS13790 2782980..2784386 + 1407 WP_134388455.1 PLP-dependent aminotransferase family protein -
E4V11_RS13795 2784631..2785776 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
E4V11_RS13800 2785794..2786807 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
E4V11_RS13805 2786808..2787749 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T288360 WP_000813794.1 NZ_LR217818:2782263-2782439 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT288360 WP_001270286.1 NZ_LR217818:2782485-2782901 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References