Detailed information of TA system TA028836

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1809024..1809549
• Replicon: chromosome
• Accession: NC_020211
• Organism: Serratia marcescens WW4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SMWW4_RS08365
• Protein ID: WP_015377296.1
• Coordinates: 1809024..1809308 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8B4GIN1
• Locus tag: SMWW4_RS08370
• Protein ID: WP_004928423.1
• Coordinates: 1809298..1809549 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMWW4_RS08340	1804284..1805417	+	1134	WP_004938650.1	putrescine ABC transporter ATP-binding subunit PotG	-
SMWW4_RS08345	1805442..1806404	+	963	WP_015377293.1	putrescine ABC transporter permease PotH	-
SMWW4_RS08350	1806401..1807246	+	846	WP_004938644.1	putrescine ABC transporter permease PotI	-
SMWW4_RS08355	1807351..1807830	+	480	WP_015377294.1	YbjO family protein	-
SMWW4_RS08360	1807900..1809027	+	1128	WP_015377295.1	23S rRNA (uracil(747)-C(5))-methyltransferase RlmC	-
SMWW4_RS08365	1809024..1809308	-	285	WP_015377296.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SMWW4_RS08370	1809298..1809549	-	252	WP_004928423.1	prevent-host-death protein	Antitoxin
SMWW4_RS08375	1809651..1810385	-	735	WP_015377297.1	arginine ABC transporter substrate-binding protein	-
SMWW4_RS08380	1810584..1811252	-	669	WP_015377298.1	arginine ABC transporter permease ArtM	-
SMWW4_RS08385	1811252..1811968	-	717	WP_015377299.1	arginine ABC transporter permease ArtQ	-
SMWW4_RS08390	1811978..1812709	-	732	WP_004928409.1	arginine ABC transporter substrate-binding protein	-
SMWW4_RS08395	1812742..1813470	-	729	WP_004928406.1	arginine ABC transporter ATP-binding protein ArtP	-
SMWW4_RS08400	1813733..1814275	-	543	WP_015377301.1	lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10803.94 Da
• Isoelectric Point: 10.6941

>T28836 WP_015377296.1 NC_020211:c1809308-1809024 [Serratia marcescens WW4]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLASVLVNPHIPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Nucleotide

• Length: 285 bp

>T28836 NC_020211:c1809308-1809024 [Serratia marcescens WW4]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGCATCGGTGCTGGTTAATCCCCACATCCCCGCCAACAAACTCGCCGGTTTGCCTGATTGCTACAAAATCA
AACTCAGAGCCTCAGGCTTTCGTTTGGTATATCGCGTCATGGAAACGGAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACGTTCAGCGGCTTACACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9108.39 Da
• Isoelectric Point: 4.5203

>AT28836 WP_004928423.1 NC_020211:c1809549-1809298 [Serratia marcescens WW4]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Nucleotide

• Length: 252 bp

>AT28836 NC_020211:c1809549-1809298 [Serratia marcescens WW4]
ATGACGGTTCAACCCATTCTTGCCGACTCGGCAGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAACCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCTCCGGAAACCTGGGAGGCGA
TCGCGGAGTACCTGGAAGATATCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GIN1