Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1567842..1568460 Replicon chromosome
Accession NZ_LR217818
Organism Escherichia coli strain NCTC86

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag E4V11_RS07675 Protein ID WP_001291435.1
Coordinates 1567842..1568060 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag E4V11_RS07680 Protein ID WP_000344800.1
Coordinates 1568086..1568460 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4V11_RS07645 1563015..1563635 + 621 WP_001267012.1 recombinase family protein -
E4V11_RS07650 1563853..1564080 + 228 WP_024183738.1 DUF2188 domain-containing protein -
E4V11_RS07655 1564424..1564777 + 354 WP_016246925.1 DUF1428 family protein -
E4V11_RS07660 1564819..1566369 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
E4V11_RS07665 1566533..1567003 - 471 WP_000136192.1 YlaC family protein -
E4V11_RS07670 1567119..1567670 - 552 WP_000102564.1 maltose O-acetyltransferase -
E4V11_RS07675 1567842..1568060 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
E4V11_RS07680 1568086..1568460 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
E4V11_RS07685 1569006..1572155 - 3150 WP_066009150.1 efflux RND transporter permease AcrB -
E4V11_RS07690 1572178..1573371 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T288353 WP_001291435.1 NZ_LR217818:c1568060-1567842 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT288353 WP_000344800.1 NZ_LR217818:c1568460-1568086 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References