Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1373048..1373742 Replicon chromosome
Accession NZ_LR217818
Organism Escherichia coli strain NCTC86

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag E4V11_RS06750 Protein ID WP_066009356.1
Coordinates 1373374..1373742 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag E4V11_RS06745 Protein ID WP_077249034.1
Coordinates 1373048..1373353 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4V11_RS06700 1368998..1369453 + 456 WP_000581506.1 hypothetical protein -
E4V11_RS06705 1369554..1369762 + 209 Protein_1286 DUF905 domain-containing protein -
E4V11_RS06715 1369863..1370684 + 822 WP_001234565.1 DUF945 domain-containing protein -
E4V11_RS06725 1371026..1371499 + 474 WP_000855059.1 antirestriction protein -
E4V11_RS06730 1371515..1371991 + 477 WP_001424026.1 RadC family protein -
E4V11_RS06735 1372060..1372281 + 222 WP_000692345.1 DUF987 domain-containing protein -
E4V11_RS06740 1372300..1372944 + 645 WP_000086755.1 hypothetical protein -
E4V11_RS06745 1373048..1373353 + 306 WP_077249034.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
E4V11_RS06750 1373374..1373742 + 369 WP_066009356.1 TA system toxin CbtA family protein Toxin
E4V11_RS06755 1374063..1374401 - 339 Protein_1294 LysR family transcriptional regulator -
E4V11_RS06760 1374452..1375408 - 957 WP_000121359.1 molybdenum cofactor insertion chaperone PaoD -
E4V11_RS06765 1375418..1377616 - 2199 WP_000667026.1 aldehyde oxidoreductase molybdenum-binding subunit PaoC -
E4V11_RS06770 1377613..1378569 - 957 WP_000643333.1 aldehyde oxidoreductase FAD-binding subunit PaoB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(3-100)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13611.75 Da        Isoelectric Point: 7.7465

>T288352 WP_066009356.1 NZ_LR217818:1373374-1373742 [Escherichia coli]
MNTLPATISPAAKPCPSPVAVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDASITLANAVNFLVEKYELVRIDRNGF
NSQVQAPYLTATDILQARKACGLMSRCSYRDVSNIVLSRSRL

Download         Length: 369 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11263.85 Da        Isoelectric Point: 6.0454

>AT288352 WP_077249034.1 NZ_LR217818:1373048-1373353 [Escherichia coli]
MVGLPYTVTPCSGTRLVQEGNRLYYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCFTLYHNGFT
CEADTLGSCGYVYIAIYPTQL

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References