Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1679731..1680284 Replicon chromosome
Accession NC_020211
Organism Serratia marcescens WW4

Toxin (Protein)


Gene name ccdB Uniprot ID A0A1Q5WDY9
Locus tag SMWW4_RS07840 Protein ID WP_015377213.1
Coordinates 1679970..1680284 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A1Q5WDV0
Locus tag SMWW4_RS07835 Protein ID WP_015377212.1
Coordinates 1679731..1679967 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMWW4_RS07820 1676197..1677732 + 1536 WP_004938996.1 glutathione ABC transporter substrate-binding protein GsiB -
SMWW4_RS07825 1677785..1678705 + 921 WP_004938995.1 glutathione ABC transporter permease GsiC -
SMWW4_RS07830 1678715..1679623 + 909 WP_015377211.1 glutathione ABC transporter permease GsiD -
SMWW4_RS07835 1679731..1679967 + 237 WP_015377212.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SMWW4_RS07840 1679970..1680284 + 315 WP_015377213.1 CcdB family protein Toxin
SMWW4_RS07845 1680321..1681163 - 843 WP_015377214.1 S-formylglutathione hydrolase -
SMWW4_RS07850 1681178..1682302 - 1125 WP_015377215.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
SMWW4_RS07855 1682332..1683252 - 921 WP_004938975.1 LysR family transcriptional regulator -
SMWW4_RS07860 1683358..1684515 + 1158 WP_004938972.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11662.55 Da        Isoelectric Point: 4.7085

>T28835 WP_015377213.1 NC_020211:1679970-1680284 [Serratia marcescens WW4]
MQFTVYANSGNSAVYPLLLDVTSDIIGQLNRRVVIPLLPVEKYPGSTRPERLIPLIRLIDDNEYAVMTYEMASIPVRALG
AEFCDVSQYRSRIKAAIDFLLDGI

Download         Length: 315 bp

>T28835 NC_020211:1679970-1680284 [Serratia marcescens WW4]
ATGCAATTTACGGTGTATGCGAATAGCGGGAACAGCGCGGTTTACCCCCTGCTGCTTGATGTGACGAGCGATATCATTGG
GCAATTAAATCGCCGAGTTGTGATCCCTTTGTTACCCGTTGAAAAATACCCGGGGAGTACGCGACCGGAGCGCTTGATCC
CGTTGATCAGATTGATTGATGACAACGAGTACGCCGTGATGACATATGAAATGGCCAGCATCCCGGTTCGGGCTTTGGGG
GCCGAATTTTGTGATGTTTCCCAGTATCGGAGCAGGATAAAAGCCGCCATCGACTTTCTTCTTGACGGTATTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9125.16 Da        Isoelectric Point: 6.4641

>AT28835 WP_015377212.1 NC_020211:1679731-1679967 [Serratia marcescens WW4]
MPVKQRTTQSVTMTLERSLLSRAREAGINLSATLTAALDAELRQHERRKWQEENREALEALNRFNDEHGCFSDEYRTF

Download         Length: 237 bp

>AT28835 NC_020211:1679731-1679967 [Serratia marcescens WW4]
ATGCCAGTAAAACAACGAACGACGCAAAGTGTGACCATGACGCTGGAACGCAGTTTGTTGAGCCGTGCGCGTGAGGCGGG
GATTAATCTCAGCGCGACGCTGACTGCTGCTTTAGATGCTGAGTTGCGTCAGCATGAGAGGAGAAAATGGCAGGAAGAAA
ACCGAGAGGCACTTGAAGCGCTTAACCGATTTAATGATGAGCATGGTTGCTTTAGCGACGAATACAGGACGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q5WDY9

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q5WDV0

References