288348

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 959044..959698 Replicon chromosome
Accession NZ_LR217818
Organism Escherichia coli strain NCTC86

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag E4V11_RS04670 Protein ID WP_000244777.1
Coordinates 959291..959698 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag E4V11_RS04665 Protein ID WP_000354046.1
Coordinates 959044..959310 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4V11_RS04645 955013..956446 - 1434 WP_001514525.1 6-phospho-beta-glucosidase BglA -
E4V11_RS04650 956491..956802 + 312 WP_001514524.1 N(4)-acetylcytidine aminohydrolase -
E4V11_RS04655 956966..957625 + 660 WP_000250274.1 hemolysin III family protein -
E4V11_RS04660 957821..958801 - 981 WP_001514522.1 tRNA-modifying protein YgfZ -
E4V11_RS04665 959044..959310 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
E4V11_RS04670 959291..959698 + 408 WP_000244777.1 toxin CptA Toxin
E4V11_RS04675 959738..960259 - 522 WP_001055874.1 flavodoxin FldB -
E4V11_RS04680 960371..961267 + 897 WP_042091714.1 site-specific tyrosine recombinase XerD -
E4V11_RS04685 961292..962002 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
E4V11_RS04690 962008..963741 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T288348 WP_000244777.1 NZ_LR217818:959291-959698 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT288348 WP_000354046.1 NZ_LR217818:959044-959310 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References