Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1620649..1621317 Replicon chromosome
Accession NZ_LR216065
Organism Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag E0F40_RS08555 Protein ID WP_001132285.1
Coordinates 1621138..1621317 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag E0F40_RS08550 Protein ID WP_000961810.1
Coordinates 1620649..1621101 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0F40_RS08530 1617498..1618532 - 1035 WP_000747915.1 ATP-binding protein -
E0F40_RS08535 1618642..1618800 - 159 WP_000401986.1 7,8-dihydro-8-oxoguanine-triphosphatase -
E0F40_RS08540 1618802..1619869 - 1068 WP_000719723.1 M50 family metallopeptidase -
E0F40_RS08545 1619888..1620358 - 471 WP_000257084.1 DUF3013 family protein -
E0F40_RS08550 1620649..1621101 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E0F40_RS08555 1621138..1621317 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
E0F40_RS08560 1621454..1621633 - 180 WP_001048906.1 hypothetical protein -
E0F40_RS08570 1621798..1622037 - 240 WP_000818078.1 hypothetical protein -
E0F40_RS08580 1622307..1623578 + 1272 WP_001113218.1 replication-associated recombination protein A -
E0F40_RS08590 1624125..1625444 - 1320 WP_000502558.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T288343 WP_001132285.1 NZ_LR216065:c1621317-1621138 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT288343 WP_000961810.1 NZ_LR216065:c1621101-1620649 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References