Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1103414..1103912 Replicon chromosome
Accession NZ_LR216065
Organism Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag E0F40_RS05845 Protein ID WP_001812387.1
Coordinates 1103414..1103668 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag E0F40_RS05850 Protein ID WP_000208080.1
Coordinates 1103670..1103912 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0F40_RS05830 1098807..1101275 - 2469 WP_001152992.1 DNA gyrase subunit A -
E0F40_RS05835 1101469..1102455 + 987 WP_000204727.1 L-lactate dehydrogenase -
E0F40_RS05840 1102715..1103367 - 653 Protein_1091 potassium channel family protein -
E0F40_RS05845 1103414..1103668 - 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E0F40_RS05850 1103670..1103912 - 243 WP_000208080.1 hypothetical protein Antitoxin
E0F40_RS05855 1104003..1104812 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
E0F40_RS05860 1104814..1106163 - 1350 WP_000886209.1 cell wall metabolism sensor histidine kinase VicK -
E0F40_RS05865 1106156..1106860 - 705 WP_000722076.1 response regulator transcription factor -
E0F40_RS05870 1106915..1108090 - 1176 WP_000886147.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.85 Da        Isoelectric Point: 10.7632

>T288341 WP_001812387.1 NZ_LR216065:c1103668-1103414 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT288341 WP_000208080.1 NZ_LR216065:c1103912-1103670 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References