Detailed information of TA system TA288340

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 955987..957224
• Replicon: chromosome
• Accession: NZ_LR216065
• Organism: Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A098ZIW8
• Locus tag: E0F40_RS05155
• Protein ID: WP_000405362.1
• Coordinates: 956463..957224 (+)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: E0F40_RS05150
• Protein ID: WP_000579613.1
• Coordinates: 955987..956463 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0F40_RS05130	951060..951914	+	855	WP_000900020.1	ADP-ribosylglycohydrolase family protein	-
E0F40_RS05135	952026..952910	+	885	WP_000710115.1	diacylglycerol kinase family lipid kinase	-
E0F40_RS05140	953073..954812	+	1740	Protein_956	alpha-glycosidase	-
E0F40_RS05145	955087..955542	+	456	WP_000500474.1	hypothetical protein	-
E0F40_RS05150	955987..956463	+	477	WP_000579613.1	helix-turn-helix domain-containing protein	Antitoxin
E0F40_RS05155	956463..957224	+	762	WP_000405362.1	toxin PezT	Toxin
E0F40_RS05160	957252..958028	+	777	Protein_960	hypothetical protein	-
E0F40_RS05165	957956..958408	+	453	WP_001835033.1	hypothetical protein	-
E0F40_RS05170	959227..959586	+	360	WP_000003745.1	hypothetical protein	-
E0F40_RS05175	959596..959961	+	366	WP_000263048.1	MobC family plasmid mobilization relaxosome protein	-
E0F40_RS05180	959948..961798	+	1851	WP_000261804.1	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	937521..977841	40320

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29129.16 Da
• Isoelectric Point: 7.1308

>T288340 WP_000405362.1 NZ_LR216065:956463-957224 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Nucleotide

• Length: 762 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18249.67 Da
• Isoelectric Point: 4.3462

>AT288340 WP_000579613.1 NZ_LR216065:955987-956463 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

Structures

Toxin

• AlphaFold DB: A0A098ZIW8