Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1172736..1173357 Replicon chromosome
Accession NC_020211
Organism Serratia marcescens WW4

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag SMWW4_RS05400 Protein ID WP_004940313.1
Coordinates 1172736..1172939 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag SMWW4_RS05405 Protein ID WP_004940312.1
Coordinates 1172989..1173357 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMWW4_RS05375 1168435..1168773 + 339 WP_004940327.1 P-II family nitrogen regulator -
SMWW4_RS05380 1168810..1170096 + 1287 WP_004940322.1 ammonium transporter AmtB -
SMWW4_RS05385 1170187..1171050 - 864 WP_015376854.1 acyl-CoA thioesterase II -
SMWW4_RS05390 1171282..1171773 + 492 WP_015376855.1 YbaY family lipoprotein -
SMWW4_RS05395 1171838..1172152 - 315 WP_015376856.1 MGMT family protein -
SMWW4_RS05400 1172736..1172939 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
SMWW4_RS05405 1172989..1173357 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
SMWW4_RS05410 1173516..1173869 - 354 WP_004940311.1 hypothetical protein -
SMWW4_RS05415 1174272..1174985 + 714 WP_015376857.1 ABC transporter ATP-binding protein -
SMWW4_RS05420 1174982..1175839 + 858 WP_015376858.1 metal ABC transporter permease -
SMWW4_RS05425 1175865..1176743 + 879 WP_015376859.1 metal ABC transporter substrate-binding protein -
SMWW4_RS05430 1176851..1176991 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
SMWW4_RS05435 1177004..1177258 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T28834 WP_004940313.1 NC_020211:c1172939-1172736 [Serratia marcescens WW4]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T28834 NC_020211:c1172939-1172736 [Serratia marcescens WW4]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCAGATCATCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT28834 WP_004940312.1 NC_020211:c1173357-1172989 [Serratia marcescens WW4]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT28834 NC_020211:c1173357-1172989 [Serratia marcescens WW4]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTATGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References