Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1610969..1611631 Replicon chromosome
Accession NZ_LR216064
Organism Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E0F31_RS08580 Protein ID WP_000192221.1
Coordinates 1611458..1611631 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag E0F31_RS08575 Protein ID WP_000961810.1
Coordinates 1610969..1611421 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0F31_RS08555 1607818..1608852 - 1035 WP_000747915.1 ATP-binding protein -
E0F31_RS08560 1608962..1609120 - 159 WP_000418159.1 7,8-dihydro-8-oxoguanine-triphosphatase -
E0F31_RS08565 1609101..1610189 - 1089 WP_000719700.1 M50 family metallopeptidase -
E0F31_RS08570 1610208..1610678 - 471 WP_000257089.1 DUF3013 family protein -
E0F31_RS08575 1610969..1611421 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E0F31_RS08580 1611458..1611631 - 174 WP_000192221.1 type II toxin-antitoxin system HicA family toxin Toxin
E0F31_RS08585 1611774..1611953 - 180 WP_001809903.1 hypothetical protein -
E0F31_RS08595 1612118..1612357 - 240 WP_000818078.1 hypothetical protein -
E0F31_RS08605 1612627..1613898 + 1272 WP_001113211.1 replication-associated recombination protein A -
E0F31_RS08615 1614442..1615761 - 1320 WP_054374557.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6368.47 Da        Isoelectric Point: 10.8214

>T288339 WP_000192221.1 NZ_LR216064:c1611631-1611458 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQAGL

Download         Length: 174 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT288339 WP_000961810.1 NZ_LR216064:c1611421-1610969 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References