Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1101579..1102077 Replicon chromosome
Accession NZ_LR216064
Organism Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6

Toxin (Protein)


Gene name relE Uniprot ID C1CEI0
Locus tag E0F31_RS05835 Protein ID WP_001823540.1
Coordinates 1101579..1101833 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag E0F31_RS05840 Protein ID WP_000208080.1
Coordinates 1101835..1102077 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0F31_RS05820 1096848..1099316 - 2469 WP_001152989.1 DNA gyrase subunit A -
E0F31_RS05825 1099510..1100496 + 987 WP_000204727.1 L-lactate dehydrogenase -
E0F31_RS05830 1100759..1101532 - 774 WP_000725951.1 ion transporter -
E0F31_RS05835 1101579..1101833 - 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E0F31_RS05840 1101835..1102077 - 243 WP_000208080.1 hypothetical protein Antitoxin
E0F31_RS05845 1102168..1102977 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
E0F31_RS05850 1102979..1104328 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
E0F31_RS05855 1104321..1105025 - 705 WP_000722076.1 response regulator transcription factor -
E0F31_RS05860 1105080..1106255 - 1176 WP_000886147.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.76 Da        Isoelectric Point: 10.9371

>T288338 WP_001823540.1 NZ_LR216064:c1101833-1101579 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT288338 WP_000208080.1 NZ_LR216064:c1102077-1101835 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C1CEI0

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References