Detailed information of TA system TA288337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 1014807..1016044
• Replicon: chromosome
• Accession: NZ_LR216064
• Organism: Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A098ZIW8
• Locus tag: E0F31_RS05395
• Protein ID: WP_000405362.1
• Coordinates: 1014807..1015568 (-)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: E0F31_RS05400
• Protein ID: WP_000579613.1
• Coordinates: 1015568..1016044 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0F31_RS05370	1010233..1012083	-	1851	WP_054363176.1	relaxase/mobilization nuclease domain-containing protein	-
E0F31_RS05375	1012070..1012435	-	366	WP_000263048.1	MobC family plasmid mobilization relaxosome protein	-
E0F31_RS05380	1012445..1012804	-	360	WP_000003745.1	hypothetical protein	-
E0F31_RS05385	1013623..1014000	-	378	Protein_1013	ATP-binding protein	-
E0F31_RS05390	1014003..1014779	-	777	Protein_1014	hypothetical protein	-
E0F31_RS05395	1014807..1015568	-	762	WP_000405362.1	toxin PezT	Toxin
E0F31_RS05400	1015568..1016044	-	477	WP_000579613.1	helix-turn-helix domain-containing protein	Antitoxin
E0F31_RS05405	1016489..1016944	-	456	WP_054363179.1	hypothetical protein	-
E0F31_RS05410	1017219..1018958	-	1740	Protein_1018	alpha-glycosidase	-
E0F31_RS05415	1019121..1020005	-	885	WP_000710115.1	diacylglycerol kinase family lipid kinase	-
E0F31_RS05420	1020117..1020971	-	855	WP_000900020.1	ADP-ribosylglycohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1006610..1031276	24666

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29129.16 Da
• Isoelectric Point: 7.1308

>T288337 WP_000405362.1 NZ_LR216064:c1015568-1014807 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Nucleotide

• Length: 762 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18249.67 Da
• Isoelectric Point: 4.3462

>AT288337 WP_000579613.1 NZ_LR216064:c1016044-1015568 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

Structures

Toxin

• AlphaFold DB: A0A098ZIW8