Detailed information of TA system TA288334

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta(toxin)
• Location: 1074801..1075978
• Replicon: chromosome
• Accession: NZ_LR216060
• Organism: Streptococcus pneumoniae strain GPSC47 substr. ST315

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: E0F39_RS05825
• Protein ID: WP_050202097.1
• Coordinates: 1075208..1075978 (+)
• Length: 257 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: E0F39_RS05820
• Protein ID: WP_078133849.1
• Coordinates: 1074801..1075208 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0F39_RS12330	1070868..1071000	-	133	Protein_1082	ISL3 family transposase	-
E0F39_RS05780	1071097..1071495	+	399	WP_050199111.1	hypothetical protein	-
E0F39_RS05785	1071967..1072197	+	231	WP_001865346.1	hypothetical protein	-
E0F39_RS05790	1072190..1072465	+	276	WP_001865345.1	type II toxin-antitoxin system RelE/ParE family toxin	-
E0F39_RS05795	1072539..1073117	+	579	WP_001865343.1	replication protein	-
E0F39_RS12070	1073129..1073284	+	156	WP_153297226.1	hypothetical protein	-
E0F39_RS05800	1073392..1073688	+	297	WP_001865342.1	hypothetical protein	-
E0F39_RS05805	1073669..1073965	+	297	WP_130886882.1	hypothetical protein	-
E0F39_RS05810	1073930..1074744	-	815	Protein_1090	IS5-like element IS1515 family transposase	-
E0F39_RS05820	1074801..1075208	+	408	WP_078133849.1	helix-turn-helix domain-containing protein	Antitoxin
E0F39_RS05825	1075208..1075978	+	771	WP_050202097.1	zeta toxin family protein	Toxin
E0F39_RS05830	1076332..1077228	-	897	WP_000384882.1	tyrosine-type recombinase/integrase	-
E0F39_RS05835	1077320..1079599	+	2280	WP_050198960.1	ATP-binding protein	-
E0F39_RS05840	1079583..1080824	-	1242	WP_001865081.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	959060..1093983	134923

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (1-35)

Sequences

Toxin

Protein

• Length: 257 a.a.
• Molecular weight: 29488.48 Da
• Isoelectric Point: 7.9259

>T288334 WP_050202097.1 NZ_LR216060:1075208-1075978 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDNFRSQHTHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYILNPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAAEVLQEYLFGKWSKVEEEML
KSGEERLKDLTNRNGC

Nucleotide

• Length: 771 bp

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15570.49 Da
• Isoelectric Point: 4.0261

>AT288334 WP_078133849.1 NZ_LR216060:1074801-1075208 [Streptococcus pneumoniae]
IGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIEIVKERGANLLSRLYRYQDSQGIS
IDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 408 bp