Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta(toxin)
Location 1074801..1075978 Replicon chromosome
Accession NZ_LR216060
Organism Streptococcus pneumoniae strain GPSC47 substr. ST315

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag E0F39_RS05825 Protein ID WP_050202097.1
Coordinates 1075208..1075978 (+) Length 257 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag E0F39_RS05820 Protein ID WP_078133849.1
Coordinates 1074801..1075208 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0F39_RS12330 1070868..1071000 - 133 Protein_1082 ISL3 family transposase -
E0F39_RS05780 1071097..1071495 + 399 WP_050199111.1 hypothetical protein -
E0F39_RS05785 1071967..1072197 + 231 WP_001865346.1 hypothetical protein -
E0F39_RS05790 1072190..1072465 + 276 WP_001865345.1 type II toxin-antitoxin system RelE/ParE family toxin -
E0F39_RS05795 1072539..1073117 + 579 WP_001865343.1 replication protein -
E0F39_RS12070 1073129..1073284 + 156 WP_153297226.1 hypothetical protein -
E0F39_RS05800 1073392..1073688 + 297 WP_001865342.1 hypothetical protein -
E0F39_RS05805 1073669..1073965 + 297 WP_130886882.1 hypothetical protein -
E0F39_RS05810 1073930..1074744 - 815 Protein_1090 IS5-like element IS1515 family transposase -
E0F39_RS05820 1074801..1075208 + 408 WP_078133849.1 helix-turn-helix domain-containing protein Antitoxin
E0F39_RS05825 1075208..1075978 + 771 WP_050202097.1 zeta toxin family protein Toxin
E0F39_RS05830 1076332..1077228 - 897 WP_000384882.1 tyrosine-type recombinase/integrase -
E0F39_RS05835 1077320..1079599 + 2280 WP_050198960.1 ATP-binding protein -
E0F39_RS05840 1079583..1080824 - 1242 WP_001865081.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 959060..1093983 134923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(1-35)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29488.48 Da        Isoelectric Point: 7.9259

>T288334 WP_050202097.1 NZ_LR216060:1075208-1075978 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDNFRSQHTHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYILNPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAAEVLQEYLFGKWSKVEEEML
KSGEERLKDLTNRNGC

Download         Length: 771 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15570.49 Da        Isoelectric Point: 4.0261

>AT288334 WP_078133849.1 NZ_LR216060:1074801-1075208 [Streptococcus pneumoniae]
IGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIEIVKERGANLLSRLYRYQDSQGIS
IDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References