Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1608448..1609116 Replicon chromosome
Accession NZ_LR216050
Organism Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag E0F32_RS08630 Protein ID WP_001132284.1
Coordinates 1608937..1609116 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag E0F32_RS08625 Protein ID WP_000961810.1
Coordinates 1608448..1608900 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0F32_RS08595 1603868..1604611 - 744 WP_001188201.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
E0F32_RS08600 1604613..1605563 - 951 WP_024477875.1 50S ribosomal protein L11 methyltransferase -
E0F32_RS08605 1605701..1606174 - 474 WP_000631889.1 GNAT family N-acetyltransferase -
E0F32_RS08610 1606171..1606599 - 429 WP_024477876.1 NUDIX hydrolase -
E0F32_RS08615 1606580..1607668 - 1089 WP_162499228.1 M50 family metallopeptidase -
E0F32_RS08620 1607687..1608157 - 471 WP_000257084.1 DUF3013 family protein -
E0F32_RS08625 1608448..1608900 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E0F32_RS08630 1608937..1609116 - 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
E0F32_RS08635 1609253..1609501 - 249 WP_000797240.1 hypothetical protein -
E0F32_RS08640 1609491..1609706 - 216 WP_075329187.1 hypothetical protein -
E0F32_RS08645 1610004..1611275 + 1272 WP_001113213.1 replication-associated recombination protein A -
E0F32_RS08655 1611823..1613142 - 1320 WP_024477878.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T288333 WP_001132284.1 NZ_LR216050:c1609116-1608937 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT288333 WP_000961810.1 NZ_LR216050:c1608900-1608448 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References