Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1131232..1131730 Replicon chromosome
Accession NZ_LR216050
Organism Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag E0F32_RS06015 Protein ID WP_001809704.1
Coordinates 1131232..1131486 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0U0E6Y1
Locus tag E0F32_RS06020 Protein ID WP_024477795.1
Coordinates 1131488..1131730 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0F32_RS06010 1129271..1131157 - 1887 WP_000150984.1 Eco57I restriction-modification methylase domain-containing protein -
E0F32_RS06015 1131232..1131486 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E0F32_RS06020 1131488..1131730 - 243 WP_024477795.1 hypothetical protein Antitoxin
E0F32_RS06025 1131821..1132630 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
E0F32_RS06030 1132632..1133981 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
E0F32_RS06035 1133974..1134678 - 705 WP_000722076.1 response regulator transcription factor -
E0F32_RS06040 1134733..1135908 - 1176 WP_000886147.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T288331 WP_001809704.1 NZ_LR216050:c1131486-1131232 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9187.42 Da        Isoelectric Point: 4.0527

>AT288331 WP_024477795.1 NZ_LR216050:c1131730-1131488 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMIHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A0U0E6Y1

References