Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 32884..33476 Replicon chromosome
Accession NZ_LR215980
Organism Paraprevotella xylaniphila YIT 11841 isolate Paraprevotella xylaniphila 82A6

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E0E47_RS00210 Protein ID WP_130892520.1
Coordinates 32884..33135 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E0E47_RS00215 Protein ID WP_130892521.1
Coordinates 33132..33476 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E47_RS00175 29021..29533 - 513 WP_130892514.1 hypothetical protein -
E0E47_RS00180 29533..30273 - 741 WP_130892515.1 ParB/RepB/Spo0J family partition protein -
E0E47_RS00185 30498..31172 - 675 WP_130892516.1 phosphoadenosine phosphosulfate reductase family protein -
E0E47_RS00190 31353..31712 - 360 WP_130892517.1 ASCH domain-containing protein -
E0E47_RS00200 32019..32351 - 333 WP_130892518.1 DUF2693 domain-containing protein -
E0E47_RS00205 32541..32831 + 291 WP_130892519.1 helix-turn-helix transcriptional regulator -
E0E47_RS00210 32884..33135 + 252 WP_130892520.1 type II toxin-antitoxin system HicA family toxin Toxin
E0E47_RS00215 33132..33476 + 345 WP_130892521.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E0E47_RS00220 33572..34087 + 516 WP_130892522.1 hypothetical protein -
E0E47_RS00225 34132..34707 + 576 WP_130892523.1 ORF6N domain-containing protein -
E0E47_RS00230 34748..35947 - 1200 WP_130892524.1 phage integrase SAM-like domain-containing protein -
E0E47_RS00240 36388..37266 - 879 WP_130892525.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD -
E0E47_RS00245 37280..38389 - 1110 WP_130892526.1 AhpC/TSA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-74)

Antitoxin

Uncharacterised protein family HicB

(56-106)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9446.00 Da        Isoelectric Point: 10.6053

>T288327 WP_130892520.1 NZ_LR215980:32884-33135 [Paraprevotella xylaniphila YIT 11841]
MGTKEKLIERFKSQPKDFSWDELVRLFSIFGYEISNKGKTSGSRVIFAKGGSSYTAHKPHPGSIVKGYVMKQVFEFLTKN
KLI

Download         Length: 252 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12550.35 Da        Isoelectric Point: 4.8604

>AT288327 WP_130892521.1 NZ_LR215980:33132-33476 [Paraprevotella xylaniphila YIT 11841]
MKTLNYKGYVGSIEISDEDNCLFGKVLDLPKDTVISYEGETVSDLKEDFKGAVDDYIAYCKEAGITPRKSYSGSLNIRIS
PEVHNKIAILAQQAGISINAFIKKAIENQIATML

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References