Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 4998768..4999294 Replicon chromosome
Accession NZ_LR215973
Organism Nocardia cyriacigeorgica strain 3012STDY6756504

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag E0E67_RS22545 Protein ID WP_130918507.1
Coordinates 4998768..4999019 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag E0E67_RS22550 Protein ID WP_197731583.1
Coordinates 4999016..4999294 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E67_RS22515 4995020..4995703 + 684 Protein_4459 ATP-binding cassette domain-containing protein -
E0E67_RS22520 4995740..4996351 + 612 WP_081597107.1 putative glycolipid-binding domain-containing protein -
E0E67_RS22525 4996485..4997495 - 1011 WP_194983655.1 prephenate dehydrogenase -
E0E67_RS22530 4997494..4998033 + 540 WP_130918506.1 tRNA adenosine deaminase-associated protein -
E0E67_RS22535 4998131..4998565 + 435 WP_130919823.1 nucleoside deaminase -
E0E67_RS22545 4998768..4999019 - 252 WP_130918507.1 Txe/YoeB family addiction module toxin Toxin
E0E67_RS22550 4999016..4999294 - 279 WP_197731583.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
E0E67_RS22555 4999349..5000323 - 975 WP_165448951.1 AraC family transcriptional regulator -
E0E67_RS22560 5000422..5001627 - 1206 WP_165448952.1 cytochrome P450 -
E0E67_RS22565 5001821..5002351 - 531 WP_165448953.1 CAP family protein -
E0E67_RS22570 5002649..5002948 - 300 WP_130918512.1 hypothetical protein -
E0E67_RS22575 5003080..5004240 + 1161 WP_130918513.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-72)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9921.14 Da        Isoelectric Point: 10.2372

>T288326 WP_130918507.1 NZ_LR215973:c4999019-4998768 [Nocardia cyriacigeorgica]
MNRTLTFTDTGWTDYLYWRHTDPATLRKVNRLIDEIRRHGNARGLGSPEPLRRNLSGWWSRRIDHEHRIVYRTDNDTVTV
IAC

Download         Length: 252 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9813.97 Da        Isoelectric Point: 4.4328

>AT288326 WP_197731583.1 NZ_LR215973:c4999294-4999016 [Nocardia cyriacigeorgica]
MHATDARINFAAVLHAATEDNDPVVITRSGGKEPAVVISLREWEAMTETAYLLSDPANAAWLAMGIAQAEAGHTTARELI
DLDAATPTEGRR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References