288320

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2395393..2396027 Replicon chromosome
Accession NZ_LR215729
Organism Pseudomonas marincola strain YSy11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PMYSY11_RS11135 Protein ID WP_150549226.1
Coordinates 2395393..2395797 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L1LS63
Locus tag PMYSY11_RS11140 Protein ID WP_003285520.1
Coordinates 2395797..2396027 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMYSY11_RS11105 2391156..2391293 - 138 WP_172970686.1 hypothetical protein -
PMYSY11_RS11110 2391591..2393000 + 1410 WP_150549223.1 site-specific integrase -
PMYSY11_RS11115 2392994..2393287 - 294 WP_150549224.1 type II toxin-antitoxin system RelE/ParE family toxin -
PMYSY11_RS11120 2393275..2393547 - 273 WP_116801393.1 CopG family ribbon-helix-helix protein -
PMYSY11_RS11125 2393949..2394281 + 333 WP_036992178.1 hypothetical protein -
PMYSY11_RS11130 2394341..2395309 + 969 WP_150549225.1 DUF932 domain-containing protein -
PMYSY11_RS11135 2395393..2395797 - 405 WP_150549226.1 tRNA(fMet)-specific endonuclease VapC Toxin
PMYSY11_RS11140 2395797..2396027 - 231 WP_003285520.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PMYSY11_RS11145 2396184..2397188 + 1005 WP_150549227.1 YqaJ viral recombinase family protein -
PMYSY11_RS11150 2397280..2398230 + 951 WP_150549228.1 hydrolase or metal-binding protein -
PMYSY11_RS11155 2398202..2398699 + 498 WP_150549229.1 DNA repair protein RadC -
PMYSY11_RS11160 2398710..2398892 + 183 WP_059319052.1 hypothetical protein -
PMYSY11_RS11165 2398993..2399979 - 987 WP_150549230.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2389121..2399979 10858


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-35)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14950.17 Da        Isoelectric Point: 7.2774

>T288320 WP_150549226.1 NZ_LR215729:c2395797-2395393 [Pseudomonas marincola]
MLKYMLDTNICIFTIKNRPEQVREAFKRHSGQLSISTVTLMELIYGAEKSANPERNLADVEGFAARLEVLPYDAQAAAHS
GQLRAELARIGKPIGPYDQMIAGHARAQGLILVTNNLREFERVPGLRVEDWVSA

Download         Length: 405 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8432.41 Da        Isoelectric Point: 4.2683

>AT288320 WP_003285520.1 NZ_LR215729:c2396027-2395797 [Pseudomonas marincola]
MEQGAVFQSNRSQAVRLPKAVALPEDVKRVDVVVVGRARIITPAGEAWDVWFDGEGVTADYMADREQPADQERDAF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L1LS63

References