Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 237568..238204 Replicon chromosome
Accession NC_020210
Organism Geobacillus sp. GHH01

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag GHH_RS01270 Protein ID WP_003253417.1
Coordinates 237854..238204 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID G8N2B5
Locus tag GHH_RS01265 Protein ID WP_011229742.1
Coordinates 237568..237849 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHH_RS01245 233826..234443 - 618 WP_011229737.1 rhomboid family intramembrane serine protease -
GHH_RS01250 234557..234919 + 363 WP_015373790.1 holo-ACP synthase -
GHH_RS01255 235025..236038 + 1014 WP_013144042.1 outer membrane lipoprotein carrier protein LolA -
GHH_RS01260 236287..237441 + 1155 WP_015373791.1 alanine racemase -
GHH_RS01265 237568..237849 + 282 WP_011229742.1 hypothetical protein Antitoxin
GHH_RS01270 237854..238204 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
GHH_RS01275 238536..240701 + 2166 WP_015373792.1 RNA-binding transcriptional accessory protein -
GHH_RS18695 240720..240833 - 114 WP_013144046.1 cortex morphogenetic protein CmpA -
GHH_RS01280 240923..241372 + 450 WP_013144047.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T28832 WP_003253417.1 NC_020210:237854-238204 [Geobacillus sp. GHH01]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T28832 NC_020210:237854-238204 [Geobacillus sp. GHH01]
TTGATTGTCAAACGTGGCGACGTGTATTTTGCGGACCTTTCCCCGGTTGTTGGCTCGGAGCAGGGCGGCGTGCGCCCCGT
GTTGGTGATCCAAAACGATATCGGCAATCGTTTTAGCCCGACGGTGATTGTCGCGGCGATTACGGCGCAAATCCAAAAAG
CGAAGCTGCCGACGCATGTCGAGATTGACGCGAAACGCTACGGGTTTGAACGCGATTCGGTCATTTTGCTTGAGCAAATT
CGCACGATCGACAAGCAACGGCTGACCGATAAAATCACTCATTTGGACGATGAAATGATGGATAAAGTCGATGAGGCGCT
GCAAATTAGCTTAGGACTGATCGACTTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10639.14 Da        Isoelectric Point: 7.2027

>AT28832 WP_011229742.1 NC_020210:237568-237849 [Geobacillus sp. GHH01]
VSESGATAEIVVRLPQSLLTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT28832 NC_020210:237568-237849 [Geobacillus sp. GHH01]
GTGTCGGAATCTGGCGCAACAGCGGAAATCGTCGTTCGTTTGCCGCAGTCGCTGCTGACAGAACTGGACGTGCTCGTAAA
GCAGGAAAACGGCAACCGCAATGAACTCATTTATCAAGCGACGAAAATGTACATTCGCGAGCGGAAGAAACGGCAAATTC
GTGAGGCGATGAGACGAGGCTACATGGAAATGGCGAAAATCAATTTATCTATCGCTTCTGAAGCGTTTCATGCTGAATAC
GAGGCCGACCACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9ETW5

References