Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1985..2544 Replicon plasmid 3
Accession NZ_LR213460
Organism Shigella sonnei strain AUSMDU00008333 isolate AUSMDU00008333

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag E0E38_RS24660 Protein ID WP_000421257.1
Coordinates 2269..2544 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag E0E38_RS24655 Protein ID WP_001178089.1
Coordinates 1985..2269 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E38_RS24640 46..1077 + 1032 WP_000907880.1 plasmid replication initiator RepA -
E0E38_RS24655 1985..2269 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
E0E38_RS24660 2269..2544 + 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E0E38_RS24665 2650..2931 + 282 WP_001105066.1 hypothetical protein -
E0E38_RS24675 3122..3388 - 267 WP_000627831.1 hypothetical protein -
E0E38_RS24685 3626..4228 - 603 WP_000517694.1 ProQ/FINO family protein -
E0E38_RS24695 4582..5928 + 1347 WP_130872907.1 protein YagA -
E0E38_RS26195 6471..6773 - 303 WP_001245884.1 hypothetical protein -
E0E38_RS24710 6770..7396 - 627 WP_000587689.1 ParA family plasmid-partitioning AAA ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(6)-Id / blaTEM-1C / aph(3'')-Ib / sul2 - 1..91948 91948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T288306 WP_000421257.1 NZ_LR213460:2269-2544 [Shigella sonnei]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT288306 WP_001178089.1 NZ_LR213460:1985-2269 [Shigella sonnei]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References