288304

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4074238..4074892 Replicon chromosome
Accession NZ_LR213458
Organism Shigella sonnei strain AUSMDU00008333 isolate AUSMDU00008333

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag E0E38_RS20625 Protein ID WP_000244777.1
Coordinates 4074238..4074645 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag E0E38_RS20630 Protein ID WP_000354046.1
Coordinates 4074626..4074892 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E38_RS20605 (4070195) 4070195..4071928 - 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -
E0E38_RS20610 (4071934) 4071934..4072644 - 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
E0E38_RS20615 (4072669) 4072669..4073565 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
E0E38_RS20620 (4073677) 4073677..4074198 + 522 WP_001055874.1 flavodoxin FldB -
E0E38_RS20625 (4074238) 4074238..4074645 - 408 WP_000244777.1 protein YgfX Toxin
E0E38_RS20630 (4074626) 4074626..4074892 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
E0E38_RS20635 (4075135) 4075135..4076115 + 981 WP_000886060.1 tRNA-modifying protein YgfZ -
E0E38_RS20640 (4076311) 4076311..4076970 - 660 WP_000250274.1 hemolysin III family protein -
E0E38_RS20645 (4077134) 4077134..4077445 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
E0E38_RS20650 (4077490) 4077490..4078923 + 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
E0E38_RS20655 (4078980) 4078980..4079723 - 744 WP_000951937.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T288304 WP_000244777.1 NZ_LR213458:c4074645-4074238 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT288304 WP_000354046.1 NZ_LR213458:c4074892-4074626 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References