Detailed information of TA system TA028830

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 2284804..2285417
• Replicon: chromosome
• Accession: NC_020209
• Organism: Pseudomonas poae RE*1-1-14

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0R2ZDN6
• Locus tag: H045_RS09825
• Protein ID: WP_015372254.1
• Coordinates: 2284804..2285055 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H045_RS09830
• Protein ID: WP_015372255.1
• Coordinates: 2285052..2285417 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H045_RS09825	2284804..2285055	+	252	WP_015372254.1	type II toxin-antitoxin system HicA family toxin	Toxin
H045_RS09830	2285052..2285417	+	366	WP_015372255.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H045_RS09835	2285458..2286813	-	1356	WP_015372256.1	MATE family efflux transporter	-
H045_RS09840	2287009..2288655	+	1647	WP_003233071.1	MCP four helix bundle domain-containing protein	-
H045_RS09845	2288690..2289160	-	471	WP_003233069.1	hypothetical protein	-
H045_RS09850	2289411..2290073	-	663	WP_015372257.1	isochorismatase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9518.11 Da
• Isoelectric Point: 10.0459

>T28830 WP_015372254.1 NC_020209:2284804-2285055 [Pseudomonas poae RE*1-1-14]
VSKNEKLLAKLLNEHMAFTWPELVTLLRRLGYTQLEGAGSRVKFDIGDPTAMITLHKPHPGNELKHYIRRQIIEQLKSGD
LIQ

Nucleotide

• Length: 252 bp

>T28830 NC_020209:2284804-2285055 [Pseudomonas poae RE*1-1-14]
GTGTCCAAAAATGAAAAGCTGCTGGCCAAATTGCTCAACGAGCACATGGCCTTTACCTGGCCCGAGCTCGTCACGCTATT
GCGTCGTCTCGGTTACACACAACTGGAAGGGGCTGGAAGCCGCGTCAAGTTCGACATCGGCGACCCGACGGCAATGATCA
CCTTGCACAAGCCTCACCCCGGCAACGAACTGAAGCATTACATTCGGCGCCAGATCATCGAACAATTGAAATCAGGAGAC
CTGATTCAGTGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13156.02 Da
• Isoelectric Point: 6.8432

>AT28830 WP_015372255.1 NC_020209:2285052-2285417 [Pseudomonas poae RE*1-1-14]
VNNQLKHKGYIGSIEASLEDNCLYGKVLFIKALLSYEGKTVAELDAAFQEAVDDYLATCQALGQTPEKPCKGSFNVRVGH
DLHLAAALEATRKKVTLNDLTRQALNEFLQQHGKAPCPAIG

Nucleotide

• Length: 366 bp

>AT28830 NC_020209:2285052-2285417 [Pseudomonas poae RE*1-1-14]
GTGAACAACCAACTGAAACACAAGGGCTACATCGGCTCTATCGAAGCCAGCCTCGAAGACAACTGCCTGTACGGCAAAGT
CCTCTTCATCAAGGCGTTGTTGAGTTACGAAGGCAAGACAGTCGCCGAGCTGGACGCGGCGTTTCAGGAGGCGGTGGACG
ATTATCTCGCCACCTGCCAGGCGCTTGGGCAAACGCCGGAAAAACCCTGCAAGGGGTCGTTCAATGTGCGGGTCGGGCAT
GACCTGCACCTGGCGGCGGCGCTTGAGGCCACCCGCAAGAAAGTCACGCTCAACGACCTGACCCGGCAAGCATTGAACGA
GTTTCTGCAACAGCACGGCAAGGCGCCCTGCCCGGCCATTGGTTGA

Structures

Toxin

• AlphaFold DB: A0A0R2ZDN6