Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1475316..1475934 Replicon chromosome
Accession NZ_LR213458
Organism Shigella sonnei strain AUSMDU00008333 isolate AUSMDU00008333

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag E0E38_RS07180 Protein ID WP_001291435.1
Coordinates 1475316..1475534 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag E0E38_RS07185 Protein ID WP_000344804.1
Coordinates 1475560..1475934 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E38_RS07145 (1470608) 1470608..1471180 + 573 WP_000779812.1 YbaY family lipoprotein -
E0E38_RS07150 (1471211) 1471211..1471522 - 312 WP_000409911.1 MGMT family protein -
E0E38_RS07160 (1471901) 1471901..1472254 + 354 WP_000878140.1 DUF1428 domain-containing protein -
E0E38_RS07165 (1472296) 1472296..1473844 - 1549 Protein_1377 cyclic-guanylate-specific phosphodiesterase PdeB -
E0E38_RS07170 (1474008) 1474008..1474478 - 471 WP_000136192.1 YlaC family protein -
E0E38_RS07175 (1474594) 1474594..1475145 - 552 WP_000102564.1 maltose O-acetyltransferase -
E0E38_RS07180 (1475316) 1475316..1475534 - 219 WP_001291435.1 HHA domain-containing protein Toxin
E0E38_RS07185 (1475560) 1475560..1475934 - 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
E0E38_RS07190 (1476480) 1476480..1479629 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
E0E38_RS07195 (1479652) 1479652..1480845 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T288295 WP_001291435.1 NZ_LR213458:c1475534-1475316 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT288295 WP_000344804.1 NZ_LR213458:c1475934-1475560 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References