288294

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1439755..1440592 Replicon chromosome
Accession NZ_LR213458
Organism Shigella sonnei strain AUSMDU00008333 isolate AUSMDU00008333

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag E0E38_RS07005 Protein ID WP_000227784.1
Coordinates 1439755..1440297 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag E0E38_RS07010 Protein ID WP_001297137.1
Coordinates 1440281..1440592 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E38_RS06975 (1434819) 1434819..1435310 + 492 WP_001138904.1 nucleotide binding protein YajQ -
E0E38_RS06980 (1435438) 1435438..1436802 - 1365 WP_001000971.1 MFS transporter -
E0E38_RS06985 (1436921) 1436921..1437618 + 698 WP_237158184.1 IS1-like element IS1A family transposase -
E0E38_RS06990 (1437987) 1437987..1438385 + 399 Protein_1342 SEL1-like repeat protein -
E0E38_RS07000 (1439133) 1439133..1439699 + 567 Protein_1344 SEL1-like repeat protein -
E0E38_RS07005 (1439755) 1439755..1440297 - 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
E0E38_RS07010 (1440281) 1440281..1440592 - 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
E0E38_RS07015 (1440777) 1440777..1441667 - 891 WP_000971327.1 heme o synthase -
E0E38_RS07020 (1441679) 1441679..1442008 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
E0E38_RS07025 (1442008) 1442008..1442622 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
E0E38_RS07030 (1442612) 1442612..1444603 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
E0E38_RS07035 (1444625) 1444625..1445572 - 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T288294 WP_000227784.1 NZ_LR213458:c1440297-1439755 [Shigella sonnei]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT288294 WP_001297137.1 NZ_LR213458:c1440592-1440281 [Shigella sonnei]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References