Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 753871..754368 Replicon chromosome
Accession NZ_LR213458
Organism Shigella sonnei strain AUSMDU00008333 isolate AUSMDU00008333

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag E0E38_RS03660 Protein ID WP_001173343.1
Coordinates 754195..754368 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag E0E38_RS03655 Protein ID WP_000398619.1
Coordinates 753871..754167 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E38_RS03635 (750602) 750602..751321 - 720 WP_000611285.1 two-component system response regulator DcuR -
E0E38_RS03640 (751318) 751318..752949 - 1632 WP_001216495.1 sensor histidine kinase -
E0E38_RS03645 (753130) 753130..753360 + 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
E0E38_RS03650 (753372) 753372..753644 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
E0E38_RS03655 (753871) 753871..754167 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
E0E38_RS03660 (754195) 754195..754368 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
E0E38_RS03665 (754487) 754487..756004 - 1518 WP_001295086.1 lysine--tRNA ligase -
E0E38_RS03670 (756241) 756241..757698 - 1458 WP_000856831.1 dipeptide/tripeptide permease DtpC -
E0E38_RS03675 (757757) 757757..758014 - 258 Protein_688 lysine decarboxylase LdcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T288292 WP_001173343.1 NZ_LR213458:754195-754368 [Shigella sonnei]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT288292 WP_000398619.1 NZ_LR213458:753871-754167 [Shigella sonnei]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References