Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 921292..921946 Replicon chromosome
Accession NZ_LR213455
Organism Shigella flexneri strain AUSMDU00008332 isolate AUSMDU00008332

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag E0E35_RS04650 Protein ID WP_000244767.1
Coordinates 921292..921699 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag E0E35_RS04655 Protein ID WP_000354044.1
Coordinates 921680..921946 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E35_RS04630 (917249) 917249..918982 - 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -
E0E35_RS04635 (918988) 918988..919698 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
E0E35_RS04640 (919723) 919723..920619 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
E0E35_RS04645 (920731) 920731..921252 + 522 WP_001055867.1 flavodoxin FldB -
E0E35_RS04650 (921292) 921292..921699 - 408 WP_000244767.1 protein YgfX Toxin
E0E35_RS04655 (921680) 921680..921946 - 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
E0E35_RS04660 (922189) 922189..923169 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
E0E35_RS04665 (923365) 923365..924024 - 660 WP_000250274.1 hemolysin III family protein -
E0E35_RS04670 (924188) 924188..924498 - 311 Protein_894 N(4)-acetylcytidine aminohydrolase -
E0E35_RS04675 (924543) 924543..925976 + 1434 WP_005051722.1 6-phospho-beta-glucosidase BglA -
E0E35_RS04680 (926033) 926033..926776 - 744 WP_000951957.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T288268 WP_000244767.1 NZ_LR213455:c921699-921292 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT288268 WP_000354044.1 NZ_LR213455:c921946-921680 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References