Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 852112..852766 Replicon chromosome
Accession NZ_LR213452
Organism Shigella flexneri strain AUSMDU00008355 isolate AUSMDU00008355

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag E0E33_RS04320 Protein ID WP_000244767.1
Coordinates 852359..852766 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag E0E33_RS04315 Protein ID WP_000354044.1
Coordinates 852112..852378 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E33_RS04290 847283..848025 + 743 Protein_828 SDR family oxidoreductase -
E0E33_RS04295 848082..849515 - 1434 WP_005076748.1 6-phospho-beta-glucosidase BglA -
E0E33_RS04300 849560..849870 + 311 Protein_830 ASCH domain-containing protein -
E0E33_RS04305 850034..850693 + 660 WP_000250274.1 hemolysin III family protein -
E0E33_RS04310 850889..851869 - 981 WP_000886065.1 tRNA-modifying protein YgfZ -
E0E33_RS04315 852112..852378 + 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
E0E33_RS04320 852359..852766 + 408 WP_000244767.1 protein YgfX Toxin
E0E33_RS04325 852806..853327 - 522 WP_001055867.1 flavodoxin FldB -
E0E33_RS04330 853439..854335 + 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
E0E33_RS04335 854360..855070 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
E0E33_RS04340 855076..856809 + 1734 WP_130862165.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T288243 WP_000244767.1 NZ_LR213452:852359-852766 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT288243 WP_000354044.1 NZ_LR213452:852112-852378 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References