Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 5131975..5132755 Replicon chromosome
Accession NC_020181
Organism Enterobacter aerogenes EA1509E

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag EAEROS_RS25030 Protein ID WP_015370123.1
Coordinates 5131975..5132304 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag EAEROS_RS25035 Protein ID WP_127175768.1
Coordinates 5132357..5132755 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAEROS_RS29020 5127347..5127499 - 153 WP_157844032.1 hypothetical protein -
EAEROS_RS27910 5127790..5128017 + 228 WP_071647620.1 DUF1272 domain-containing protein -
EAEROS_RS25010 5128345..5129163 + 819 WP_032706441.1 AraC family transcriptional regulator -
EAEROS_RS25015 5129239..5129601 + 363 WP_015370120.1 cupin domain-containing protein -
EAEROS_RS25020 5129801..5130337 + 537 WP_015370121.1 dihydrofolate reductase family protein -
EAEROS_RS25025 5130513..5131313 + 801 WP_015370122.1 nucleotidyltransferase domain-containing protein -
EAEROS_RS29025 5131472..5131573 - 102 Protein_4760 preprotein translocase -
EAEROS_RS25030 5131975..5132304 - 330 WP_015370123.1 TA system toxin CbtA family protein Toxin
EAEROS_RS25035 5132357..5132755 - 399 WP_127175768.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EAEROS_RS25040 5132724..5132945 - 222 WP_015370125.1 DUF987 domain-containing protein -
EAEROS_RS25045 5132966..5133445 - 480 WP_015370126.1 DNA repair protein RadC -
EAEROS_RS25050 5133457..5133936 - 480 WP_032710462.1 antirestriction protein -
EAEROS_RS27915 5133953..5134207 - 255 WP_071647618.1 hypothetical protein -
EAEROS_RS25055 5134207..5135025 - 819 WP_015370128.1 DUF945 domain-containing protein -
EAEROS_RS25060 5135123..5135356 - 234 WP_015370129.1 DUF905 domain-containing protein -
EAEROS_RS25065 5135450..5136286 - 837 WP_015370130.1 hypothetical protein -
EAEROS_RS25070 5136344..5136592 - 249 WP_134875004.1 hypothetical protein -
EAEROS_RS25075 5136589..5136816 - 228 WP_015370132.1 hypothetical protein -
EAEROS_RS25080 5136889..5137296 - 408 WP_032710459.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(33-131)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12493.28 Da        Isoelectric Point: 7.3984

>T28824 WP_015370123.1 NC_020181:c5132304-5131975 [Klebsiella aerogenes EA1509E]
MQTLSLHPTRATQPYLSPVETWQRLLTHLLSEHYGLTLNDTPFSYETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILMARRSTGLLKTTVK

Download         Length: 330 bp

>T28824 NC_020181:c5132304-5131975 [Klebsiella aerogenes EA1509E]
ATGCAAACCTTATCATTACACCCGACAAGGGCGACTCAGCCCTATCTGTCACCCGTTGAAACCTGGCAACGGCTGCTGAC
TCATCTTTTATCGGAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTTATGAAACCACCATACGGGAACATATTG
ATGCAGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATACGGGCTTGTCCGTATCGACCGGAAAGGATTT
TCATGGCAAGAACAGACCCCGTATATTTCCGTAGTAGATATTCTGATGGCAAGGCGCTCGACCGGCCTGCTAAAAACTAC
CGTGAAATAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14730.76 Da        Isoelectric Point: 7.0372

>AT28824 WP_127175768.1 NC_020181:c5132755-5132357 [Klebsiella aerogenes EA1509E]
MSSCAASRSINVNLRKAKLSNEIPAVNHDIAEPWWGLKTTVTPYFGARLVQEGNRLHYLADRASITGTFSDADLRHLDQA
FPVLLKQLELMLVSGELTSRHQHRITLYHNGLTCEADTLGSCGYVYIAIYPD

Download         Length: 399 bp

>AT28824 NC_020181:c5132755-5132357 [Klebsiella aerogenes EA1509E]
ATGTCGTCCTGCGCAGCGTCACGCTCAATTAACGTTAATTTAAGGAAAGCTAAATTGTCGAATGAAATACCGGCAGTAAA
CCACGATATTGCCGAACCCTGGTGGGGACTCAAAACCACCGTCACGCCGTACTTTGGCGCACGACTGGTGCAGGAAGGCA
ACCGGCTGCATTACCTGGCTGATCGTGCCAGTATCACCGGGACATTCAGCGACGCGGATTTACGCCATCTCGACCAGGCG
TTTCCGGTATTGCTTAAACAGCTGGAGTTGATGCTCGTTTCCGGTGAGCTCACCTCCCGCCATCAGCACCGCATCACGCT
ATATCACAATGGACTGACTTGCGAAGCCGATACACTCGGCTCTTGTGGTTACGTCTACATCGCTATTTATCCCGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References