Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 427251..427822 Replicon chromosome
Accession NZ_LR135782
Organism Enterococcus faecium isolate E4239

Toxin (Protein)


Gene name mazF Uniprot ID A0A828ZXV4
Locus tag EQB67_RS02225 Protein ID WP_002302307.1
Coordinates 427481..427822 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag EQB67_RS02220 Protein ID WP_002323011.1
Coordinates 427251..427481 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB67_RS02180 422728..424059 + 1332 WP_002346495.1 FAD-dependent oxidoreductase -
EQB67_RS02185 424081..424707 + 627 WP_002346494.1 cysteine hydrolase -
EQB67_RS02190 424900..425481 + 582 WP_002300332.1 TetR/AcrR family transcriptional regulator -
EQB67_RS02205 425845..426420 + 576 WP_002302305.1 SOS response-associated peptidase family protein -
EQB67_RS02210 426625..426963 - 339 WP_002286804.1 hypothetical protein -
EQB67_RS02220 427251..427481 + 231 WP_002323011.1 hypothetical protein Antitoxin
EQB67_RS02225 427481..427822 + 342 WP_002302307.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EQB67_RS02235 430288..432792 + 2505 WP_002323736.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13288.65 Da        Isoelectric Point: 9.9044

>T288236 WP_002302307.1 NZ_LR135782:427481-427822 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIISQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT288236 WP_002323011.1 NZ_LR135782:427251-427481 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXV4

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References