Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4794446..4795103 Replicon chromosome
Accession NC_020181
Organism Enterobacter aerogenes EA1509E

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag EAEROS_RS23415 Protein ID WP_015369792.1
Coordinates 4794693..4795103 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag EAEROS_RS23410 Protein ID WP_015369791.1
Coordinates 4794446..4794712 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAEROS_RS23385 4789673..4791106 - 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -
EAEROS_RS23390 4791226..4791954 - 729 WP_015369788.1 MurR/RpiR family transcriptional regulator -
EAEROS_RS23395 4792005..4792316 + 312 WP_015369789.1 N(4)-acetylcytidine aminohydrolase -
EAEROS_RS23400 4792481..4793140 + 660 WP_008806429.1 hemolysin III family protein -
EAEROS_RS23405 4793239..4794222 - 984 WP_015369790.1 tRNA-modifying protein YgfZ -
EAEROS_RS23410 4794446..4794712 + 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
EAEROS_RS23415 4794693..4795103 + 411 WP_015369792.1 protein YgfX Toxin
EAEROS_RS23420 4795111..4795632 - 522 WP_015369793.1 flavodoxin FldB -
EAEROS_RS23425 4795733..4796629 + 897 WP_015369794.1 site-specific tyrosine recombinase XerD -
EAEROS_RS23430 4796652..4797365 + 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EAEROS_RS23435 4797371..4799104 + 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T28823 WP_015369792.1 NC_020181:4794693-4795103 [Klebsiella aerogenes EA1509E]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T28823 NC_020181:4794693-4795103 [Klebsiella aerogenes EA1509E]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTAATCGACTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAGCCGG
CGCACGACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT28823 WP_015369791.1 NC_020181:4794446-4794712 [Klebsiella aerogenes EA1509E]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT28823 NC_020181:4794446-4794712 [Klebsiella aerogenes EA1509E]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGATAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References