Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 36703..37222 Replicon plasmid 3
Accession NZ_LR135477
Organism Enterococcus faecium isolate E8423

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag EQB52_RS15545 Protein ID WP_000588503.1
Coordinates 36965..37222 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag EQB52_RS15540 Protein ID WP_000388479.1
Coordinates 36703..36972 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB52_RS15515 33242..34636 + 1395 Protein_41 type I restriction-modification system subunit M -
EQB52_RS15520 34691..35371 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
EQB52_RS15525 35447..36013 + 567 Protein_43 hypothetical protein -
EQB52_RS15535 36393..36572 + 180 WP_001120991.1 hypothetical protein -
EQB52_RS15540 36703..36972 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQB52_RS15545 36965..37222 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
EQB52_RS15550 37860..38684 + 825 WP_001809248.1 hypothetical protein -
EQB52_RS15555 38849..39463 - 615 WP_001261742.1 recombinase family protein -
EQB52_RS15560 39913..41238 + 1326 WP_000969590.1 Y-family DNA polymerase -
EQB52_RS15565 41231..41581 + 351 WP_000568378.1 hypothetical protein -
EQB52_RS15570 41578..41757 + 180 WP_001021554.1 hypothetical protein -
EQB52_RS15575 41893..42183 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) / aph(3')-III / VanHAX - 1..44000 44000


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T288225 WP_000588503.1 NZ_LR135477:36965-37222 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT288225 WP_000388479.1 NZ_LR135477:36703-36972 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References