Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 460538..461067 Replicon chromosome
Accession NZ_LR135475
Organism Enterococcus faecium isolate E8423

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag EQB52_RS02335 Protein ID WP_002296560.1
Coordinates 460538..460804 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag EQB52_RS02340 Protein ID WP_002296559.1
Coordinates 460804..461067 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB52_RS02305 455938..456342 - 405 WP_002287522.1 IS200/IS605-like element ISEfa4 family transposase -
EQB52_RS02310 456500..457081 + 582 Protein_415 CBS domain-containing protein -
EQB52_RS02315 457085..457726 + 642 WP_002293405.1 ABC transporter permease -
EQB52_RS02320 457723..458640 + 918 WP_002296564.1 osmoprotectant ABC transporter substrate-binding protein -
EQB52_RS02325 458637..459308 + 672 WP_002302663.1 ABC transporter permease -
EQB52_RS02330 459849..460337 - 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
EQB52_RS02335 460538..460804 - 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
EQB52_RS02340 460804..461067 - 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQB52_RS02350 461543..461728 + 186 WP_002296558.1 transcriptional regulator -
EQB52_RS02355 461870..463693 - 1824 WP_002294202.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T288221 WP_002296560.1 NZ_LR135475:c460804-460538 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT288221 WP_002296559.1 NZ_LR135475:c461067-460804 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References