Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 450961..451532 Replicon chromosome
Accession NZ_LR135474
Organism Enterococcus faecium isolate E9101

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag EQB44_RS02360 Protein ID WP_002286801.1
Coordinates 451191..451532 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag EQB44_RS02355 Protein ID WP_002323011.1
Coordinates 450961..451191 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB44_RS02320 446441..447769 + 1329 WP_002327434.1 FAD-containing oxidoreductase -
EQB44_RS02325 447791..448417 + 627 WP_002286816.1 cysteine hydrolase -
EQB44_RS02330 448600..449181 + 582 WP_002327433.1 TetR/AcrR family transcriptional regulator -
EQB44_RS02340 449546..450121 + 576 WP_002327432.1 SOS response-associated peptidase family protein -
EQB44_RS02345 450327..450701 - 375 WP_158076077.1 hypothetical protein -
EQB44_RS02355 450961..451191 + 231 WP_002323011.1 hypothetical protein Antitoxin
EQB44_RS02360 451191..451532 + 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EQB44_RS02365 452382..452567 + 186 WP_002304207.1 hypothetical protein -
EQB44_RS02370 452837..453999 + 1163 WP_086956687.1 IS3 family transposase -
EQB44_RS12480 454247..454372 + 126 WP_025478972.1 LPXTG cell wall anchor domain-containing protein -
EQB44_RS02380 454446..455342 + 897 WP_002327428.1 class C sortase -
EQB44_RS02385 455523..456197 + 675 WP_002291233.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T288219 WP_002286801.1 NZ_LR135474:451191-451532 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT288219 WP_002323011.1 NZ_LR135474:450961-451191 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References