288218

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 183996..184525 Replicon chromosome
Accession NZ_LR135474
Organism Enterococcus faecium isolate E9101

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag EQB44_RS00980 Protein ID WP_002294198.1
Coordinates 184259..184525 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag EQB44_RS00975 Protein ID WP_002294199.1
Coordinates 183996..184259 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB44_RS00960 181371..183194 + 1824 WP_002328658.1 APC family permease -
EQB44_RS00965 183336..183521 - 186 WP_002294201.1 hypothetical protein -
EQB44_RS00975 183996..184259 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQB44_RS00980 184259..184525 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
EQB44_RS00985 184726..185214 + 489 WP_002328659.1 hypothetical protein -
EQB44_RS00990 185756..186427 - 672 WP_002319469.1 ABC transporter permease -
EQB44_RS00995 186424..187341 - 918 WP_002301114.1 osmoprotectant ABC transporter substrate-binding protein -
EQB44_RS01000 187338..187979 - 642 WP_002293405.1 ABC transporter permease -
EQB44_RS01005 187983..189158 - 1176 WP_002328660.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T288218 WP_002294198.1 NZ_LR135474:184259-184525 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT288218 WP_002294199.1 NZ_LR135474:183996-184259 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References