Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2608013..2608584 Replicon chromosome
Accession NZ_LR135443
Organism Enterococcus faecium isolate E7114

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag FSA55_RS12835 Protein ID WP_002286801.1
Coordinates 2608243..2608584 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag FSA55_RS12830 Protein ID WP_002323011.1
Coordinates 2608013..2608243 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FSA55_RS12805 2603146..2604477 + 1332 WP_002286818.1 FAD-containing oxidoreductase -
FSA55_RS12810 2604499..2605125 + 627 WP_002286816.1 cysteine hydrolase -
FSA55_RS12815 2605308..2605889 + 582 WP_002286813.1 TetR/AcrR family transcriptional regulator -
FSA55_RS12820 2606621..2607183 + 563 Protein_2472 SOS response-associated peptidase family protein -
FSA55_RS12825 2607388..2607726 - 339 WP_002286804.1 hypothetical protein -
FSA55_RS12830 2608013..2608243 + 231 WP_002323011.1 hypothetical protein Antitoxin
FSA55_RS12835 2608243..2608584 + 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FSA55_RS12840 2609434..2609619 + 186 WP_002304207.1 hypothetical protein -
FSA55_RS12845 2610124..2610318 + 195 WP_002297028.1 hypothetical protein -
FSA55_RS12850 2610509..2610758 + 250 Protein_2478 transposase -
FSA55_RS12855 2611002..2611832 - 831 WP_002286789.1 manganese catalase family protein -
FSA55_RS12860 2612040..2613374 + 1335 WP_002303373.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T288212 WP_002286801.1 NZ_LR135443:2608243-2608584 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT288212 WP_002323011.1 NZ_LR135443:2608013-2608243 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References