Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 91451..92022 Replicon plasmid 2
Accession NZ_LR135436
Organism Enterococcus faecium isolate E8691

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EQB50_RS14020 Protein ID WP_002322675.1
Coordinates 91681..92022 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EQB50_RS14015 Protein ID WP_002322676.1
Coordinates 91451..91681 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB50_RS13990 86523..87077 - 555 WP_002295761.1 tyrosine-type recombinase/integrase -
EQB50_RS13995 87820..88380 + 561 WP_002347210.1 hypothetical protein -
EQB50_RS14000 88413..89225 - 813 WP_002322679.1 AAA family ATPase -
EQB50_RS14005 89218..90654 - 1437 WP_002322678.1 DDE-type integrase/transposase/recombinase -
EQB50_RS14010 90626..91219 - 594 WP_002322677.1 recombinase family protein -
EQB50_RS14015 91451..91681 + 231 WP_002322676.1 hypothetical protein Antitoxin
EQB50_RS14020 91681..92022 + 342 WP_002322675.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EQB50_RS14025 92236..93738 - 1503 WP_002322674.1 xylulokinase -
EQB50_RS14030 93811..94863 - 1053 WP_002323515.1 sugar ABC transporter substrate-binding protein -
EQB50_RS14035 94916..95884 - 969 WP_002322672.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..144068 144068


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13232.43 Da        Isoelectric Point: 9.4128

>T288208 WP_002322675.1 NZ_LR135436:91681-92022 [Enterococcus faecium]
MTEEKNYIPKKGDIVWIDFDPSAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIRNFPTRYSLPTELDTTGQILISQ
LKSLDFNERKLKKIESLPLQDMAKIDQMIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8551.48 Da        Isoelectric Point: 4.0070

>AT288208 WP_002322676.1 NZ_LR135436:91451-91681 [Enterococcus faecium]
MLITKSRLQGSSVVITLPSDNGKKPSENKEYIVIYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLSPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References