288206

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 188348..189456 Replicon plasmid 2
Accession NZ_LR135429
Organism Enterococcus faecium isolate E8927

Toxin (Protein)


Gene name MNTss Uniprot ID A0A0M4MHJ8
Locus tag EQB53_RS14280 Protein ID WP_002303392.1
Coordinates 188348..189217 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID B9DSK1
Locus tag EQB53_RS14285 Protein ID WP_002303393.1
Coordinates 189232..189456 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB53_RS14245 183783..184520 - 738 WP_002292226.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
EQB53_RS14250 184645..184728 - 84 WP_031929417.1 23S rRNA methyltransferase attenuator leader peptide ErmL -
EQB53_RS14260 185266..186060 - 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
EQB53_RS14265 186153..186695 - 543 WP_000627290.1 streptothricin N-acetyltransferase Sat4 -
EQB53_RS14270 186692..187600 - 909 WP_001255866.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
EQB53_RS14275 187633..188367 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
EQB53_RS14280 188348..189217 - 870 WP_002303392.1 nucleotidyltransferase domain-containing protein Toxin
EQB53_RS14285 189232..189456 - 225 WP_002303393.1 helix-turn-helix transcriptional regulator Antitoxin
EQB53_RS14290 189599..190420 - 822 Protein_190 recombinase zinc beta ribbon domain-containing protein -
EQB53_RS14295 191108..191911 - 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
EQB53_RS14300 191965..193449 - 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -
EQB53_RS14305 193892..194455 - 564 Protein_193 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32807.38 Da        Isoelectric Point: 4.7269

>T288206 WP_002303392.1 NZ_LR135429:c189217-188348 [Enterococcus faecium]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8351.65 Da        Isoelectric Point: 4.5357

>AT288206 WP_002303393.1 NZ_LR135429:c189456-189232 [Enterococcus faecium]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGDEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4MHJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A1M5SHM7

References