Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
Location | 13653..14790 | Replicon | plasmid 4 |
Accession | NZ_LR135422 | ||
Organism | Enterococcus faecium isolate E8440 |
Toxin (Protein)
Gene name | zeta | Uniprot ID | - |
Locus tag | FQ475_RS16110 | Protein ID | WP_074394525.1 |
Coordinates | 13653..14516 (-) | Length | 288 a.a. |
Antitoxin (Protein)
Gene name | epsilon | Uniprot ID | Q9AL01 |
Locus tag | FQ475_RS16115 | Protein ID | WP_002331065.1 |
Coordinates | 14518..14790 (-) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FQ475_RS16075 | 8894..9151 | + | 258 | WP_002326781.1 | hypothetical protein | - |
FQ475_RS16080 | 9403..9975 | - | 573 | WP_000170424.1 | recombinase family protein | - |
FQ475_RS16085 | 9991..10596 | - | 606 | WP_000599739.1 | Fic family protein | - |
FQ475_RS16090 | 10997..11566 | - | 570 | Protein_12 | FtsX-like permease family protein | - |
FQ475_RS16095 | 11618..12298 | - | 681 | WP_001067799.1 | IS6-like element IS1216 family transposase | - |
FQ475_RS16100 | 12445..12528 | + | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
FQ475_RS16105 | 12653..13390 | + | 738 | WP_002321849.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
FQ475_RS16110 | 13653..14516 | - | 864 | WP_074394525.1 | zeta toxin family protein | Toxin |
FQ475_RS16115 | 14518..14790 | - | 273 | WP_002331065.1 | antitoxin | Antitoxin |
FQ475_RS16120 | 14807..15016 | - | 210 | WP_000527318.1 | peptide-binding protein | - |
FQ475_RS16125 | 15115..16011 | - | 897 | WP_002334978.1 | AAA family ATPase | - |
FQ475_RS16130 | 16309..16881 | - | 573 | WP_001079938.1 | HTH domain-containing protein | - |
FQ475_RS16135 | 17157..17951 | - | 795 | WP_001096887.1 | aminoglycoside O-phosphotransferase APH(3')-IIIa | - |
FQ475_RS16140 | 18044..18586 | - | 543 | WP_000627290.1 | streptothricin N-acetyltransferase Sat4 | - |
FQ475_RS16145 | 18583..19491 | - | 909 | WP_001255866.1 | aminoglycoside nucleotidyltransferase ANT(6)-Ia | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | erm(B) / aph(3')-III / ant(6)-Ia | - | 1..26633 | 26633 | |
- | inside | IS/Tn | erm(B) / aph(3')-III / ant(6)-Ia | - | 11618..19491 | 7873 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 288 a.a. Molecular weight: 32611.17 Da Isoelectric Point: 6.6627
>T288202 WP_074394525.1 NZ_LR135422:c14516-13653 [Enterococcus faecium]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEALISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQLPTPPIPKTPKLPGI
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEALISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQLPTPPIPKTPKLPGI
Download Length: 864 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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