Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2677276..2677895 Replicon chromosome
Accession NC_020181
Organism Enterobacter aerogenes EA1509E

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag EAEROS_RS13490 Protein ID WP_015367918.1
Coordinates 2677677..2677895 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag EAEROS_RS13485 Protein ID WP_015367917.1
Coordinates 2677276..2677650 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAEROS_RS13475 2672435..2673634 + 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EAEROS_RS13480 2673657..2676803 + 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit -
EAEROS_RS13485 2677276..2677650 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
EAEROS_RS13490 2677677..2677895 + 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
EAEROS_RS13495 2678027..2678590 + 564 WP_015367919.1 maltose O-acetyltransferase -
EAEROS_RS13500 2678716..2679180 + 465 WP_015367920.1 YlaC family protein -
EAEROS_RS13505 2679155..2680609 - 1455 WP_015367921.1 PLP-dependent aminotransferase family protein -
EAEROS_RS13510 2680712..2681422 + 711 WP_015367922.1 GNAT family N-acetyltransferase -
EAEROS_RS13515 2681419..2681559 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EAEROS_RS13520 2681562..2681822 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2677276..2687878 10602


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T28820 WP_015367918.1 NC_020181:2677677-2677895 [Klebsiella aerogenes EA1509E]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T28820 NC_020181:2677677-2677895 [Klebsiella aerogenes EA1509E]
ATGTCTGGTAAACCATTAACTAAAACAGACTATTTGATGCGTTTACGCCGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAGAATAAATATGAACTTTCCGACAATGAATTGGCGGTATTTTACTCAGCAGCCGACCATCGTCTTGCTGAAT
TGACCATGAATAAGCTATACGACAAAATCCCAACTTCAGTATGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT28820 WP_015367917.1 NC_020181:2677276-2677650 [Klebsiella aerogenes EA1509E]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT28820 NC_020181:2677276-2677650 [Klebsiella aerogenes EA1509E]
ATGGACGAGTACTCGCCAAAAAGACATGATATCGCGCAGCTAAGATTTCTCTGCGAAACGTTGTATCATGACTGCCTTGC
AAACCTGGAAGAAAGCAACCGCGGCTGGGTTAACGATCCCACCTCGGCGGTGAATCTTCAATTAAATGAATTGATCGAGC
ACATAGCAACTTACGCGCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATTTCTCAGCTTGATGAATACCTG
GATGACACTTTTATGCTGTTCAGTAGCTATGGCATAAACACAAGCGATCTCCAAAAATGGCGCAAATCCGGCAATCGGTT
ATTCCGATGCTTTGTGAACGCCAGCCGGGAGAACCCGGCAAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References