288184

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 40589..41697 Replicon plasmid 3
Accession NZ_LR135396
Organism Enterococcus faecium isolate E8290

Toxin (Protein)


Gene name MNTss Uniprot ID -
Locus tag EQB51_RS16545 Protein ID WP_060763469.1
Coordinates 40589..41458 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag EQB51_RS16550 Protein ID WP_000205227.1
Coordinates 41473..41697 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB51_RS16515 36659..37231 - 573 WP_001079938.1 HTH domain-containing protein -
EQB51_RS16525 37507..38301 - 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
EQB51_RS16530 38394..38936 - 543 WP_000627290.1 streptothricin N-acetyltransferase Sat4 -
EQB51_RS16535 38933..39841 - 909 WP_001255866.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
EQB51_RS16540 39874..40608 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
EQB51_RS16545 40589..41458 - 870 WP_060763469.1 nucleotidyltransferase domain-containing protein Toxin
EQB51_RS16550 41473..41697 - 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
EQB51_RS16555 41840..43402 - 1563 WP_000136908.1 recombinase family protein -
EQB51_RS16560 43404..43820 - 417 WP_000323438.1 recombinase -
EQB51_RS16565 43821..44117 - 297 WP_002360685.1 hypothetical protein -
EQB51_RS16570 44629..45306 - 678 Protein_51 DNA topoisomerase -
EQB51_RS16575 45322..45924 - 603 WP_001062586.1 recombinase family protein -
EQB51_RS17010 45938..46108 - 171 WP_000713595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid VanHBX / erm(B) / aph(3')-III / ant(6)-Ia - 1..63798 63798
- inside IScluster/Tn VanHBX / erm(B) / aph(3')-III / ant(6)-Ia - 22860..39841 16981


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32777.35 Da        Isoelectric Point: 4.7269

>T288184 WP_060763469.1 NZ_LR135396:c41458-40589 [Enterococcus faecium]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT288184 WP_000205227.1 NZ_LR135396:c41697-41473 [Enterococcus faecium]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References