Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1360398..1361137 Replicon chromosome
Accession NC_020181
Organism Enterobacter aerogenes EA1509E

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag EAEROS_RS07285 Protein ID WP_032705770.1
Coordinates 1360652..1361137 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag EAEROS_RS07280 Protein ID WP_015366659.1
Coordinates 1360398..1360664 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAEROS_RS07255 1355706..1356575 + 870 WP_015366654.1 5'/3'-nucleotidase SurE -
EAEROS_RS07260 1356829..1357308 + 480 Protein_1262 response regulator transcription factor -
EAEROS_RS07265 1357404..1357901 + 498 WP_015366656.1 heme-binding protein -
EAEROS_RS07270 1358302..1358835 + 534 WP_100280375.1 N-acetyltransferase -
EAEROS_RS07275 1358890..1360125 - 1236 WP_015366658.1 MFS transporter -
EAEROS_RS07280 1360398..1360664 + 267 WP_015366659.1 DUF1778 domain-containing protein Antitoxin
EAEROS_RS07285 1360652..1361137 + 486 WP_032705770.1 GNAT family N-acetyltransferase Toxin
EAEROS_RS07290 1361209..1362825 + 1617 WP_015366662.1 FAD-NAD(P)-binding protein -
EAEROS_RS07295 1362944..1364044 + 1101 WP_015366663.1 NADH:flavin oxidoreductase/NADH oxidase -
EAEROS_RS27055 1364101..1364259 - 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
EAEROS_RS07305 1364520..1365590 + 1071 WP_015366664.1 mannonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17573.23 Da        Isoelectric Point: 8.8793

>T28818 WP_032705770.1 NC_020181:1360652-1361137 [Klebsiella aerogenes EA1509E]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHSEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T28818 NC_020181:1360652-1361137 [Klebsiella aerogenes EA1509E]
ATGGGAAAAATAAGCGCGCCTGCACCGCTATCTTCACACCATCAGATCGCGGAATTTTGTTGTGGAGAAACGGTTCTCGA
TCAATGGCTGAAACAGCGAGGATTGAAAAACCAGGCACAGGGCGCCGCGAGAACCTTTGTGGTCTGCAAGGAAGAGAGCC
ATCAGGTGGTGGGGTTTTATTCGTTAGCAACCGGCAGCGTTAATCACTCGGAAGCCACTGGCGGCCTGCGGCGCAATATG
CCCGATCCTATCCCGGTCATCATTCTCGCCCGCCTGGCGATCGACTGCGCGTTTCACGGACAGGGGCTGGGAGCTGATTT
ACTCCATGATGCGCTGTTACGCAGTTATCGCGTTGCCGAAAATGTTGGCGTACGTGCCCTGATGGTCCATGCCCTGACCG
ATAGCGCGAAACGATTCTATTTACACCACGGATTCAAAGCCTCAACCACCCAGGAACGCACTCTTTTCCTCGCGTTGCCT
AAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10075.52 Da        Isoelectric Point: 4.6558

>AT28818 WP_015366659.1 NC_020181:1360398-1360664 [Klebsiella aerogenes EA1509E]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANSALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT28818 NC_020181:1360398-1360664 [Klebsiella aerogenes EA1509E]
ATGAAATCAGATATCCAACTCAACATCCGGGCGAAGGAGTCCCAGCGGGCGCTGATTGATGCGGCTGCCGAAATTCTGCA
CAAATCACGGACCGACTTTATTCTTGAGATGGCTTGCCAGGCGGCAGAAAACGTCATTCTCGACCGCCGGGTGTTTAACT
TAAGCGATGAGCAATACGCCGAATTTATCGACATGCTGGATGCGCCGGTTGAAGCTAACTCCGCTCTCGATAAATTGCTG
GCGAGAAAACCACAATGGGAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References