Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 13675..14783 Replicon plasmid 4
Accession NZ_LR135387
Organism Enterococcus faecium isolate E7933

Toxin (Protein)


Gene name MNTss Uniprot ID -
Locus tag EQB43_RS16995 Protein ID WP_060763469.1
Coordinates 13675..14544 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag EQB43_RS17000 Protein ID WP_000205227.1
Coordinates 14559..14783 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB43_RS16965 9745..10317 - 573 WP_001079938.1 HTH domain-containing protein -
EQB43_RS16975 10593..11387 - 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
EQB43_RS16980 11480..12022 - 543 WP_000627290.1 streptothricin N-acetyltransferase Sat4 -
EQB43_RS16985 12019..12927 - 909 WP_001255866.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
EQB43_RS16990 12960..13694 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
EQB43_RS16995 13675..14544 - 870 WP_060763469.1 nucleotidyltransferase domain-containing protein Toxin
EQB43_RS17000 14559..14783 - 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
EQB43_RS17005 14926..16488 - 1563 WP_000136908.1 recombinase family protein -
EQB43_RS17010 16490..16906 - 417 WP_000323438.1 recombinase -
EQB43_RS17015 16907..17203 - 297 WP_002360685.1 hypothetical protein -
EQB43_RS17020 17715..18392 - 678 Protein_25 DNA topoisomerase -
EQB43_RS17025 18408..19010 - 603 WP_001062586.1 recombinase family protein -
EQB43_RS17665 19024..19194 - 171 WP_000713595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid erm(B) / aph(3')-III / ant(6)-Ia / VanHBX - 1..62379 62379
- inside IS/Tn erm(B) / aph(3')-III / ant(6)-Ia - 5054..12927 7873


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32777.35 Da        Isoelectric Point: 4.7269

>T288179 WP_060763469.1 NZ_LR135387:c14544-13675 [Enterococcus faecium]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT288179 WP_000205227.1 NZ_LR135387:c14783-14559 [Enterococcus faecium]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References