Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 92137..92708 Replicon plasmid 2
Accession NZ_LR135373
Organism Enterococcus faecium isolate E8172

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EQB36_RS14230 Protein ID WP_002322675.1
Coordinates 92367..92708 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EQB36_RS14225 Protein ID WP_002322676.1
Coordinates 92137..92367 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB36_RS14200 87209..87763 - 555 WP_002295761.1 tyrosine-type recombinase/integrase -
EQB36_RS14205 88506..89066 + 561 WP_002347210.1 hypothetical protein -
EQB36_RS14210 89099..89911 - 813 WP_002322679.1 AAA family ATPase -
EQB36_RS14215 89904..91340 - 1437 WP_002322678.1 DDE-type integrase/transposase/recombinase -
EQB36_RS14220 91312..91905 - 594 WP_002322677.1 recombinase family protein -
EQB36_RS14225 92137..92367 + 231 WP_002322676.1 hypothetical protein Antitoxin
EQB36_RS14230 92367..92708 + 342 WP_002322675.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EQB36_RS14235 92922..94424 - 1503 WP_002322674.1 xylulokinase -
EQB36_RS14240 94497..95549 - 1053 WP_002323515.1 sugar ABC transporter substrate-binding protein -
EQB36_RS14245 95602..96570 - 969 WP_002322672.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..156371 156371


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13232.43 Da        Isoelectric Point: 9.4128

>T288172 WP_002322675.1 NZ_LR135373:92367-92708 [Enterococcus faecium]
MTEEKNYIPKKGDIVWIDFDPSAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIRNFPTRYSLPTELDTTGQILISQ
LKSLDFNERKLKKIESLPLQDMAKIDQMIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8551.48 Da        Isoelectric Point: 4.0070

>AT288172 WP_002322676.1 NZ_LR135373:92137-92367 [Enterococcus faecium]
MLITKSRLQGSSVVITLPSDNGKKPSENKEYIVIYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLSPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References