Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Xre-MNT/HTH_26(antitoxin) |
| Location | 5177..6285 | Replicon | plasmid 3 |
| Accession | NZ_LR135366 | ||
| Organism | Enterococcus faecium isolate E8195 | ||
Toxin (Protein)
| Gene name | MNTss | Uniprot ID | - |
| Locus tag | EQB49_RS15850 | Protein ID | WP_060763469.1 |
| Coordinates | 5177..6046 (-) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | Xress | Uniprot ID | - |
| Locus tag | EQB49_RS15855 | Protein ID | WP_000205227.1 |
| Coordinates | 6061..6285 (-) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EQB49_RS15820 | 1247..1819 | - | 573 | WP_001079938.1 | HTH domain-containing protein | - |
| EQB49_RS15830 | 2095..2889 | - | 795 | WP_001096887.1 | aminoglycoside O-phosphotransferase APH(3')-IIIa | - |
| EQB49_RS15835 | 2982..3524 | - | 543 | WP_000627290.1 | streptothricin N-acetyltransferase Sat4 | - |
| EQB49_RS15840 | 3521..4429 | - | 909 | WP_001255866.1 | aminoglycoside nucleotidyltransferase ANT(6)-Ia | - |
| EQB49_RS15845 | 4462..5196 | - | 735 | WP_000662263.1 | class I SAM-dependent methyltransferase | - |
| EQB49_RS15850 | 5177..6046 | - | 870 | WP_060763469.1 | nucleotidyltransferase domain-containing protein | Toxin |
| EQB49_RS15855 | 6061..6285 | - | 225 | WP_000205227.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| EQB49_RS15860 | 6428..7990 | - | 1563 | WP_000136908.1 | recombinase family protein | - |
| EQB49_RS15865 | 7992..8408 | - | 417 | WP_000323438.1 | recombinase | - |
| EQB49_RS15875 | 8831..9979 | - | 1149 | WP_002287525.1 | IS200/IS605 family element transposase accessory protein TnpB | - |
| EQB49_RS15880 | 9996..10400 | - | 405 | WP_002287522.1 | IS200/IS605-like element ISEfa4 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aph(3')-III / ant(6)-Ia / erm(B) | - | 1..31867 | 31867 | |
| - | inside | IScluster/Tn | aph(3')-III / ant(6)-Ia | - | 25..14735 | 14710 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 32777.35 Da Isoelectric Point: 4.7269
>T288169 WP_060763469.1 NZ_LR135366:c6046-5177 [Enterococcus faecium]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
Download Length: 870 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|