Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2101784..2102355 Replicon chromosome
Accession NZ_LR135357
Organism Enterococcus faecium isolate E7948

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag EQB40_RS10670 Protein ID WP_002286801.1
Coordinates 2101784..2102125 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag EQB40_RS10675 Protein ID WP_002323011.1
Coordinates 2102125..2102355 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQB40_RS10640 2096994..2098328 - 1335 WP_002286788.1 ABC transporter substrate-binding protein -
EQB40_RS10645 2098536..2099366 + 831 WP_002286789.1 manganese catalase family protein -
EQB40_RS10655 2099610..2099892 - 283 Protein_1980 transposase -
EQB40_RS10660 2100050..2100244 - 195 WP_002297028.1 hypothetical protein -
EQB40_RS10665 2100749..2100934 - 186 WP_002304207.1 hypothetical protein -
EQB40_RS10670 2101784..2102125 - 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EQB40_RS10675 2102125..2102355 - 231 WP_002323011.1 hypothetical protein Antitoxin
EQB40_RS10685 2102642..2102980 + 339 WP_002286804.1 hypothetical protein -
EQB40_RS10690 2103185..2103424 - 240 WP_002321938.1 SOS response-associated peptidase family protein -
EQB40_RS10695 2103400..2103747 - 348 WP_002286808.1 SOS response-associated peptidase family protein -
EQB40_RS10715 2104479..2105060 - 582 WP_002286813.1 TetR/AcrR family transcriptional regulator -
EQB40_RS10720 2105243..2105869 - 627 WP_002286816.1 cysteine hydrolase -
EQB40_RS10725 2105891..2107222 - 1332 WP_002286818.1 FAD-containing oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T288161 WP_002286801.1 NZ_LR135357:c2102125-2101784 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT288161 WP_002323011.1 NZ_LR135357:c2102355-2102125 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References